Which three substances are commonly noted for requiring detoxification?

The substances commonly noted for requiring detoxification are alcohol, CNS depressants, and opiates. Detoxification is a critical initial step in the treatment process for individuals who are physically dependent on certain substances because withdrawal symptoms can be severe and sometimes life-threatening.

Alcohol is known to cause significant withdrawal symptoms, which can range from mild anxiety and tremors to severe complications such as delirium tremens, a potentially fatal condition. CNS depressants, which include substances like benzodiazepines, also carry a high risk of severe withdrawal effects that necessitate medical detoxification supervision. Opiates, such as heroin or prescription painkillers, create a physical dependence that leads to distressing withdrawal symptoms including pain, nausea, and intense cravings.

The other options list combinations of substances that either do not typically require medical detoxification or are not classified in the same high-risk category for withdrawal. Cocaine, for instance, does not usually lead to physical dependence that requires detoxification, while hallucinogens and methamphetamine do not commonly result in severe withdrawal symptoms that necessitate a medically supervised detox.